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Nexxt Spine, LLC announced the development of NanoMatrixx, a porous bioactive titanium material designed to actively participate in the intervertebral fusion process.

Nexxt Spine’s NanoMatrixx is manufactured to exacting specifications utilizing modern 3D printing technology to replicate the cellular structure of cancellous bone. This process makes it possible to create any three dimensional complex structure or geometry with a desired modulus of elasticity that cannot be created by traditional orthopedic manufacturing processes.

Following the manufacturing process, the material undergoes a series of proprietary treatments to produce a micro and nanosurface topography which stimulates mesenchymal stem cells to differentiate into bone forming osteoblast cells that produce bone growth onto and throughout the 3-D printed material.

According to Dr. Robert L. Wertz, Director of New Product Development, “A glimpse inside of the NanoMatrixx material reveals its uniform 3-dimensional cellular architecture with 70% porosity. The cubical shaped scaffold provides an optimal biomechanical and biological environment for uninterrupted blood flow. Every surface of the NanoMatrixx material exhibits a micro and nanotextured topography that’s designed to elicit a superior osteogenic response. This allows bone to attach to the internal struts and grow entirely through the material while simultaneously providing optimal mechanical support without the stress shielding effects experienced with traditional titanium implants.

“Conventional textured or coated implant surfaces only achieve bone to implant contact or on-growth; however, NanoMatrixx’s consistent open and interconnected network of pores within a specific size range have been found to be osteoconductive and osteoinductive, promoting bone on-growth and bone in-growth for total osseous integration. Bone has the potential to not only grow into the pores and around the struts, but also attach to the nanotextured strut surfaces.”

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